题目：Tuning Regioselectivity in the [3+2] Cycloaddition of Alkynyl Sulfonium Salts with Binucleophilic N-Aryl Amidines

作者：Zhi Li, Zhengjun He, Qiang Huang*, Mei Kan, Hongji Li*

单位：Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

摘要：A tunable reaction manifold of alkynyl sulfonium salts with binucleophilic N-aryl amidines in the absence of any transition metal catalyst is first reported. This methodology involves sequential addition/cyclization that is perfectly tuned by stepwise addition of K₂CO₃, affording a plethora of valuable 1,2,4- and 1,2,5-trisubstituted imidazoles in good yields with high regioselectivity. Importantly, trapping and isolation of the reactive intermediate unveiled the reaction mechanism of β-attack on the triple bond in this [3+2] cycloaddition reaction.

影响因子：5.2

分区情况：一区

链接：https://doi.org/10.1021/acs.orglett.4c01534